Ion Channel Pharmacology
Due to the recent development of successful new screening technologies, there has been a dramatic increase in interest in ion channels as drug targets. The proliferation of ion channel screening programmes requires electrophysiology support for hit validation, potency determination, selectivity profiling and lead optimization. Cerebrasol Ltd. aims to provide vital world class electrophysiological support for ion channel drug discovery programmes.
Ion Channel Analysis at Cerebrasol Ltd. includes:
- Whole-cell patch clamp recordings and single channel recordings from cell lines stably expressing ligand or voltage-gated channels.
- Whole-cell patch clamp recordings and single channel recordings from freshly dissociated and primary cultured neurones
- Perforated patch and intracellular recordings for G-protein coupled receptors and signal transduction pathways
Cerebrasol’ expert ion channel pharmacologists can provide important information on compound potency, mechanism of action and selectivity:
- Mechanism of action
- Kinetics of modulation
- Site of compound interaction
- Single channel analysis